Pilot Study of Curcumin for Women With Obesity and High Risk for Breast Cancer

PRIMARY OBJECTIVES: i.) To determine whether nanoemulsion curcumnin modulates pro-inflammatory biomarkers in plasma and breast adipose tissue. SECONDARY OBJECTIVES include: ii.) To determine the adherence, tolerability and safety of two doses of nanoemulsion curcumin (NEC) in women at high risk for developing breast cancer; iii.) Evaluate possible correlations between physical factors such as body mass index (BMI), dietary intake and pro-inflammatory effects in plasma and breast adipose tissue. iv.) Explore additional biomarkers as surrogate endpoints to measure effects of NEC. OUTLINE: Participants are randomized to 1 of 2 arms. ARM I: Participants receive lower dose of nanoemulsion curcumin orally (PO) twice daily (BID) for 3 months. ARM II: Participants receive 100 mg of nanoemulsion curcumin PO BID for 3 months.