Gene Therapy After Frontline Chemotherapy in Treating Patients With AIDS-Related Non-Hodgkin Lymphoma

Inclusion Criteria

• •HIV-1 seropositive at or before the time of lymphoma diagnosis
• •Karnofsky performance status \>= 70%
• •Biopsy proven NHL, including plasmablastic lymphoma and primary effusion lymphoma but not T-cell lymphoma; tissue histology will be reviewed at City of Hope (COH); patients who have been in remission for \> 1 year post Hodgkin's lymphoma chemotherapy are also considered eligible
• •\>= 28 days from completion of frontline chemotherapy for NHL
• •If remission status \< 1 year for NHL, complete remission documented by computed tomography (CT) or positron emission tomography (PET)-CT scan within 3 months of study entry
• •No diagnosed psychosocial conditions that would hinder study compliance and follow-up
• •Pretreatment serum glutamic oxaloacetic transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) =\< 2.5 x institutional upper limit of normal (ULN)
• •Pretreatment serum bilirubin =\< 2.5 x institutional ULN or - Total bilirubin \< 4.5 mg/dl with direct fraction =\< 0.3 mg/dl in patients for whom these abnormalities are felt to be due to protease inhibitor therapy
• •Serum creatinine \< 2 x the institutional ULN
• •Absence of clinically significant cardiomyopathy, congestive heart failure
• •Cardiac ejection fraction has to be \>= 50%
• •Spirometry diffusion capacity (diffusion capacity of the lung for carbon monoxide \[DLCO\]) \>= 50%
• •If the subject is female and of child-bearing potential, subject must have negative serum or urine pregnancy test within 7 days of treatment with research agent; men with partners of child-bearing potential and women of child-bearing potential must be willing to use medically effective birth control methods, e.g. contraceptive pill, condom, or diaphragm and continue this for one year post HSPC infusion
• •Subjects must be on a prophylactic regimen for Pneumocystis carinii pneumonia, or agree to begin such treatment, if the cluster of differentiation (CD)4 counts are \< 200 cells/uL
• •SECONDARY ELIGIBILITY CRITERIA FOR GENE-MODIFIED HSPC INFUSION:
• •Subjects must complete the filgrastim (G-CSF)/plerixafor mobilization of peripheral blood progenitor cells and must have collected at least 7.5 x 10\^6 CD34+ cells/kg, sufficient for preparation of both, a back-up of 2.5 x 10\^6 CD34+ cells and the research product
• •Research product must pass all release tests
• •Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control or abstinence) prior to study entry and for six months following duration of study participation; should a woman become pregnant or suspect that she is pregnant while participating on the trial, she should inform her treating physician immediately
• •All subjects must have the ability to understand and the willingness to sign a written informed consent