Lumpectomy Followed By Intraoperative Electron Radiation Therapy (IOERT)

Inclusion Criteria

• •Patient agrees to breast conservation therapy (segmental resection, partial mastectomy, and radiation therapy) as the treatment for their breast cancer
• •Patient agrees to evaluation of the axilla with sentinel lymph node biopsy
• •Peri or post-menopausal women age \> 50, defined as women who have experienced no menstrual period in the past 6 months or more
• •BRCA1 and 2 gene mutation negative, if tested. \[genetic testing is NOT required based upon personal or family history\]
• •Unifocal (unicentric), invasive ductal carcinoma or favorable sub-types (mucinous, tubular, colloid) \< 2.0 cm in diameter, primary T-stage of Tis or T1 (AJCC criteria)
• •Grade 1, 2, or 3 acceptable
• •Associated LCIS is allowed
• •Pure DCIS allowed if \<2.5 cm, low to intermediate nuclear grade and resected margins negative at \> 3 mm (per ASTRO criteria)
• •Estrogen receptor (ER) status of positive
• •Patient has clear margins \>2 mm on gross pathologic examination
• •Patient is node-negative, defined as N0 (i-) or N0 (i+)
• •Patient must be deemed functionally and mentally competent to understand and sign the informed consent
• •Neoadjuvant hormonal therapy is allowed if all other ASTRO suitable criteria have been met prior to onset of hormonal therapy