Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Michigan
Age
30–any
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
30 years or older;
diagnosis of limited or diffuse scleroderma (American College of Rheumatology criteria)
for the "high risk" group, one of the following features:
* resting transthoracic echocardiogram showing elevated right-sided pressures within previous 3 months \[tricuspid regurgitation (TR) jet \>2.8 m/s or evidence of right ventricular dysfunction\]
* pulmonary function testing (PFT) showing abnormal diffusing capacity of carbon monoxide (DLCO) not due to significant interstitial lung disease (DLCO\<60% predicted or FVC: DLCO ratio \>1.4)
You may not be if
Pregnancy
prior diagnosis of pulmonary hypertension
treatment with endothelin receptor antagonists, phosphodiesterase-5 inhibitors, or prostacyclin analogues
previous diagnosis of obstructive lung disease or pulmonary thromboembolic disease
current smoker
significant valvular disease
resting echocardiogram showing left ventricular ejection fraction\<50% within previous 3 months
resting echocardiogram showing significant (greater than Grade I) diastolic dysfunction
pulmonary emboli (past or present).
Clareo Health | Novel Screening Strategies for Scleroderma PAH
