Effects of PINTA 745 in End Stage Renal Disease (ESRD) Patients Who Require Hemodialysis and Have Protein Energy Wasting

Exclusion Criteria

• •Presence of an indwelling central vascular catheter
• •Current medical condition that would interfere with ability to perform physical function tests
• •Active infection requiring hospitalization or antibiotics within the past month
• •Major surgery within past 3 months, minor surgery within the past 4 months
• •Dialysis access revision/angioplasty/replacement within the past 2 weeks
• •History of renal transplant, whether or not functional, within 2 years (however, if graft has been removed, patient will be considered eligible) or plans to undergo renal transplantation within 6 months
• •History of neoplasia, except non-melanoma skin cancers, with a 30% probability of recurrence within 12 months
• •Current treatment with appetite stimulants, anabolic steroids or growth hormone
• •Clinically significant heart disease
• •Difficulty swallowing food or liquid
• •If female, currently breast feeding
• •If female, pregnant
• •If female or male, unwilling to use a highly effective method of contraception