Study of Cryoablation for Metastatic Lung Tumors

Inclusion Criteria

• •Participant must be at least 18 years old.
• •Participant has signed a written informed consent.
• •Participant presents with Stage 4 pulmonary metastatic disease with metastatic disease previously confirmed by prior biopsy; or Participant presents with Stage 4 pulmonary metastatic disease previously confirmed on imaging (for example, computerized tomography or CT) with histology proven primary cancer.
• •Participant has up to 6 local pulmonary metastases targetable by cryoablation.
• •Targeted index tumor(s) defined as intra pulmonary or pleural with a maximum size of 3.5 cm, measured in the longest cross-sectional dimension.
• •The target index tumor(s) is determined (by CT images) to be in a location where cryoablation is technically achievable based on the proximity of adjacent organs/ structures and is greater than 0.5 cm from any critical organ/structure (possibly achieved with additional maneuvers such as iatrogenic pneumothorax or hydrodissection).
• •Karnofsky Performance Scale (KPS) score greater than or equal to 60.
• •Platelet count greater than 50,000/millimeters (mm)\^3 within 8 weeks prior to initial cryoablation procedure.
• •International Normalized Ratio (INR) less than 1.5 within 8 weeks prior to initial cryoablation procedure.
• •Participant has a life expectancy of greater than 3 months.