PRIMARY OBJECTIVES:
I. To establish the safety and feasibility of collecting, analyzing and storing clinically annotated panomic and other data from serially monitored subjects with metastatic triple negative breast cancer (TNBC) who receive care from up to ten oncology practices across the United States.
SECONDARY OBJECTIVES:
I. To determine whether molecular changes associated with resistance to treatment can be identified.
II. To understand subject perceptions regarding panomic data and its application to cancer treatment.
III. To apply other technologies to the characterization of subject tumors as they become available.
OUTLINE:
Patients undergo collection of tissue biopsy, blood, buccal mucosa, saliva, and urine at baseline. Additional biopsies may be performed prior to treatment change.
After completion of biopsy, patients are followed up at 1 day and 7 days. Patients will be followed indefinitely or for as long as they agree to be in the study, depending on the availability of resources.
