A Proof of Concept Study to Assess Effect of Fluticasone Furoate (FF)/Levocabastine Fixed Dose Combination (FDC) Compared With Levocabastine and FF Alone in Subjects With Allergic Rhinitis (AR)

Exclusion Criteria

• •Body weight \>=50 kg and body mass index (BMI) within the range 19-30 kilogram per meter suare (kg/m\^2) (inclusive).
• •A female subject is eligible to participate if she is of:
• •Non-childbearing potential defined as pre-menopausal females with a documented tubal ligation or hysterectomy \[for this definition, "documented" refers to the outcome of the investigator's/designee's review of the subject's medical history for study eligibility, as obtained via a verbal interview with the subject or from the subject's medical records\]; or postmenopausal defined as 12 months of spontaneous amenorrhea (in questionable cases a blood sample with simultaneous follicle stimulating hormone \[FSH\] \>40 milli international unit per milliliter (MIU/milliliter \[mL\]) and estradiol \<40 picogram per milliliter\[pg/mL\] (\<147 picomole per liter \[pmol/L\]) is confirmatory).
• •Child-bearing potential with negative pregnancy test as determined by urine beta-human chorionic gonadotropin (β-hCG) test at screening or prior to dosing and;
• •Agrees to use one of the contraception methods for an appropriate period of time (as determined by the product label or investigator) prior to the start of dosing to sufficiently minimize the risk of pregnancy at that point. Female subjects must agree to use contraception until 1 week post-last dose
• •Capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the consent form.
• •Subjects should be non-smokers, which for this study is defined as having smoked \<10 packs per year in their lifetime, and have not smoked in the 6 months prior to the screening visit.
• •alanine aminotransferase (ALT), alkaline phosphatase and bilirubin \<=1.5x upper limit of normal (ULN) (isolated bilirubin \>1.5xULN is acceptable if bilirubin is fractionated and direct bilirubin \<35%).
• •Based on single or averaged corrected QT interval (QTc) values of triplicate electrocardiogram (ECGs) obtained over a brief recording period: Fridericia's QTC (QTcF) \<450 milliseconds (msec).
• •Nasal abnormalities likely to affect the outcome of the study, that is nasal septal perforation, nasal polyps, sinusitis other nasal malformations.
• •History of frequent nose bleeds
• •Patients with rhinitis medicamentosa
• •Current or chronic history of liver disease, or known hepatic or biliary abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones).
• •Significant renal impairment, which based on the opinion of the investigator, would preclude the subjects participation in the study.
• •History of regular alcohol consumption within 6 months of the study defined as:
• •An average weekly intake of \>21 units for males or \>14 units for females. One unit is equivalent to 8 gram of alcohol: a half-pint (\~240 mL) of beer, 1 glass (125 mL) of wine or 1 (25 mL) measure of spirits.
• •History of sensitivity to any of the study medications, or components thereof or a history of drug or other allergy that, in the opinion of the investigator or GSK Medical Monitor, contraindicates their participation.
• •A positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody result within 3 months of screening
• •A positive pre-study drug/alcohol screen.
• •A positive test for human immunodeficiency virus (HIV) antibody.