Effects of HX106 on Improvement in Cognitive-Bio-Markers of Memory Function

Effects of HX106 on Improvement in Cognitive-Bio-Markers of Memory Function in Healthy Adults With Subjective Memory Complaints

NCT01956097•Ewha Womans University

View on ClinicalTrials.gov

Summary

The objectives of the current study are to evaluate the efficacy and safety of HX106 in healthy adults with subjective memory complaints for improving cognitive and neurobiolgoical markers of memory.

Detailed Description

The objectives of the current study are to evaluate the efficacy and safety of HX106 in healthy adults with subjective memory complaints for improving neurocognitive functions and to find the changes of brain using magnetic resonance imaging and their associations with the neurocognitive function enhancement.

Eligibility

Age

20 - 60 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Age between 20 and 60 years old,
•Global Deterioration Scale score (GDS) of 2
•One or more symptoms of subjective memory impairment
•High school or higher levels of education.

Exclusion Criteria

•Current pregnancy or breast-feeding
•Evidence of neurologic or medical conditions
•Axis I diagnosis when assessed by the board certified psychiatrist using the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorder, 4th edition (DSM-IV)(SCID-IV),
•One or more major depressive episode during last 12 months
•Mini-mental status examination score of 24 or less
•Clinical Dementia Rating score of 0.5 or more suggesting cognitive impairment beyond self-perceived subjective deficits
•Intelligence quotient less than 80
•Any history of head trauma involving loss of consciousness or seizure
•Contraindications to magnetic resonance imaging (MRI)
•Use of psychotropics in last 3 months
+2 more criteria

Locations (1)

Ewha W. University

Seoul, South Korea

Key Dates

Start Date

March 1, 2012

Primary Completion Date

January 1, 2013

Completion Date

January 1, 2013

Last Updated

August 22, 2025

Enrollment

ACTUAL participants

Conditions

Healthy Adults With Subjective Memory Complaints

Interventions

HX106 590mg

DIETARY_SUPPLEMENT

HX106 1180mg

DIETARY_SUPPLEMENT

Placebo

DIETARY_SUPPLEMENT