Adjuvant Radiation for High Risk Bladder Cancer

Exclusion Criteria

• •Patients with metastatic disease outside of the pelvis
• •Prior invasive malignancy (except non-melanomatous skin cancer) unless disease free for a minimum of 3 years
• •Prior radiation therapy to the pelvis
• •Patients with active inflammatory bowel disease
• •Severe acute co-morbidity, defined as follows:
• •* Unstable angina and/or congestive heart failure requiring hospitalization in the last 3 months
• •* Transmural myocardial infarction within the last 6 months
• •* Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration
• •* Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of registration
• •* Acquired immune deficiency syndrome (AIDS) based upon current Centers for Disease Control and Prevention (CDC) definition; note, however, that human immunodeficiency virus (HIV) testing is not required for entry into this protocol; the need to exclude patients with AIDS from this protocol is necessary because the treatment involved in this protocol may be significantly immunosuppressive; protocol-specific requirements may also exclude immunocompromised patients