Imaging and Genetic Investigation of Learning and Decision Making

Exclusion Criteria

• •Subjects will not be eligible for this study if they:
• •have a major medical (e.g. heart disease), neurological (e.g. stroke) or psychiatric (e.g. bipolar disorder) illness
• •have a vision and/or hearing problem that interferes with testing
• •currently use any psychotropic medication, antidepressants, steroids or opiates
• •currently use alcohol in excess of 14 drinks/week for males or 7 drinks/week for females.
• •have a lifetime history of or currently have alcohol or substance use or dependence (excluding nicotine) that requires independent, concurrent treatment intervention (such as, antabuse or opiate treatment). This does not include self-help group treatment/intervention.
• •cannot understand the consent and procedures or cannot consent themselves to the study
• •Smoke more than a half pack of cigarettes a day
• •NIMH employees and staff and their immediate family members will be excluded from the study per NIMH policy.
• •Female subjects who are pregnant or have a positive pregnancy test 24 hours prior to an experiment will be excluded from neuroimaging studies.
• •All subjects will be questioned prior to MRI scanning for possible occupational exposure to metal slivers or shavings, which may have become accidentally lodged in the tissues of the head or neck. Subjects with surgical clips or shrapnel in or near the brain or blood vessels, subjects with cochlear implants, subjects with any metallic body in the eye or CNS, and subjects with any form of implant wire or metal device which may concentrate radiofrequency fields will be excluded from MRI scanning experiments because of possible risks during MRI scanning. Those whose history is suggestive of such a problem will also be excluded from the MRI portion of the experiments. They may still participate in the behavioral experiments.
• •Subjects unable to lie flat on their back for up to 2 hours or who are uncomfortable in small close spaces (have claustrophobia) will not be eligible to participate in MRI scans.