Hypofractionated Proton Beam Therapy for Localized Prostate Cancer

Exclusion Criteria

• •Prior or concurrent invasive malignancy (except non-melanomatous skin cancer or lymphomatous/hematogenous malignancy) unless continually disease free for a minimum of 5 years
• •Evidence of distant metastases
• •Regional lymph node involvement
• •Previous prostatectomy, cryosurgery, or high intensity focused ultrasound (HIFU) for prostate cancer
• •Previous pelvic radiation or prostate brachytherapy
• •Active and severe medical co-morbidity defined as follows: unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months, transmural myocardial infarction within the last 6 months, acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration, chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of registration, hepatic insufficiency resulting in clinical jaundice, active inflammatory bowel disease (Crohn's disease or ulcerative colitis), diagnosed connective tissue disorder, or congenital coagulation defects (patients on medical therapy with Coumadin or other blood thinning agents are eligible for participation)