Nintedanib in Treating Patients With Advanced Non-Small Cell Lung Cancer Who Have Failed Up to Two Previous Chemotherapy Regimens

Patients with any known endothelial growth factor receptor (EGFR) mutation and/or anaplastic lymphoma receptor tyrosine kinase (ALK) translocation

Symptomatic, untreated, or uncontrolled central nervous system (CNS) metastases or seizure disorder; patients with asymptomatic CNS metastases treated with whole brain radiation (WBRT) or gamma knife radiosurgery (GKR) may be enrolled \>= 1 week after completion of WBRT/GKR provided toxicities are =\< Common Toxicity Criteria (CTC) grade I at the time of registration and/or controlled with dexamethasone 2 mg once daily for at least 5 days at the time of study treatment; patients with symptomatic CNS metastases treated with WBRT/GKR may be enrolled \>= 2 weeks after completion of WBRT/GKR provided toxicities are =\< CTC grade 1 at the time of registration and neurologic symptoms controlled with dexamethasone =\< 2 mg once daily for at least 1 week at the time of study treatment

Patients receiving palliative radiation to skeletal metastases may be registered as early as 1 week after completion of radiation therapy provided toxicities are =\< CTC grade I at the time of registration

Any of the following prior therapies for malignancy:

* Systemic chemotherapy =\< 4 weeks prior to registration

* Radiation therapy =\< 4 weeks prior to registration (exceptions noted in the prior bullet); the site of previous radiotherapy should have evidence of progressive disease if this is the only site of disease

* Major surgery (i.e., laparotomy), open biopsy, or significant traumatic injury =\< 4 weeks prior to registration; minor surgery =\< 2 weeks prior to registration; insertion of a vascular access device is not considered major or minor surgery in this regard

* Other investigational agent =\< 30 days prior to study treatment

The following patients will be excluded from this study:

* Pregnant women

* Breastfeeding women

* Men or women who are sexually active and unwilling to use a medically acceptable method of contraception (e.g., such as implants, injectables, combined oral contraceptives, some intrauterine devices or vasectomized partner for participating females, condoms for participating males) during the trial and for at least three months after end of active therapy; a highly effective method of birth control is defined as one which results in a low failure rate (i.e., less than 1% per year) when used consistently and correctly; patients will be considered to be of childbearing potential unless surgically sterilized by hysterectomy or bilateral tubal ligation/salpingectomy, or post-menopausal for at least 2 years

Second primary malignancy with the following exceptions which are allowed:

* Carcinoma in situ of the cervix

* Non-melanoma skin cancer

* History of low-grade (Gleason score =\< 6) localized prostate cancer even if diagnosed \< 5 years prior to registration

* Treated stage I breast cancer even if diagnosed =\< 5 years prior to registration

* Other prior malignancy (including melanoma) allowed if it was diagnosed and definitively treated at least 5 years previously with no subsequent evidence of recurrence

Impairment of gastrointestinal function or gastrointestinal disease that may significantly alter the absorption of BIBF 1120 (e.g., ulcerative disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome or extensive small bowel resection)

Leptomeningeal disease

Human immunodeficiency virus (HIV)-positive patients receiving combination anti-retroviral therapy are excluded because of possible pharmacokinetic interactions with oral investigational agents

Unwilling to, or unable to, comply with the protocol

Uncontrolled intercurrent illness including, but not limited to ongoing or active infection requiring systemic antimicrobial therapy (including history of active or chronic hepatitis C and/or hepatitis B infection), significant pulmonary symptoms at baseline due to disease, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements

Centrally located tumors with radiographic evidence (computed tomography \[CT\] or magnetic resonance imaging \[MRI\]) of local invasion of major blood vessels

Significant weight loss (\> 10% of baseline body mass) within past 6 months prior to inclusion into the study

Coagulation parameters: International normalized ratio (INR) \> 2, prothrombin time (PT) and partial thromboplastin time (PTT) \> 50% of deviation of institutional ULN

Proteinuria by Common Terminology Criteria for Adverse Events (CTCAE) grade 2 or greater

Known inherited predisposition to bleeding or thrombosis

Therapeutic anticoagulation (except for low-dose heparin and/or heparin flush as needed for maintenance of an in-dwelling intravenous device) or anti-platelet therapy (except for low-dose therapy with acetylsalicylic acid \< 325 mg per day)

Baseline hemoptysis, per clinician/investigator evaluation

Active alcohol or drug abuse

History of arterial or venous thrombotic/embolic events =\< 12 months prior to registration

Prior history with BIBF 1120 or any other vascular endothelial growth factor (VEGF)/VEGF receptor (R) inhibitor

New York Heart Association (NYHA) class III or IV; NOTE: patients classified as NYHA class II controlled with treatment may participate, with increased monitoring

What this study is about