T and B Cell Responses in Autoimmune Diseases

This is a non-randomized, multi-center clinical research study. Subjects who are healthy or have a confirmed or suspected diagnosis of type 1diabetes, multiple sclerosis, psoriasis, Crohn's disease, or rheumatoid arthritis will be asked to donate a blood sample. No follow-ups are planned. Investigators will: * evaluate immune cells from subjects enrolled in this study and match the differences to types of immune cells known to cause autoimmune diseases * investigate a particular disease pathway: the IL23R signaling cascade.