Cirrhosis

Inadequate liver function

Co-infection with hepatitic C virus (HCV), HIV or hepatitic D virus (HDV)

Evidence of hepatocellular carcinoma

Significant cardiovascular, pulmonary, or neurological disease

Females who are pregnant or may wish to become pregnant during the study

Received solid organ or bone marrow transplant

Use of another investigational agents within 3 months of screening

Current alcohol or substance abuse judged by the investigator to potentially interfere with compliance

History of demyelinating disease (Guillain-Barre), Bell's Palsy, Crohn's disease ulcerative colitis, autoimmune disease

Known hypersensitivity to study drug, metabolites or formulation excipients

Safety and Efficacy of GS-4774 for the Treatment of Chronic Hepatitis B