Study of Airway Inflammation in Relation to Exercise in Elite Athletes

Competitive swimmers, competitive indoor athletes and control individuals performing sports at a recreational level will be recruited for the study. They will perform a sport-specific training (swimmers and controls: swimming for 90 minutes, indoor athletes: basketball or volleyball for 90 minutes) Baseline measurements: * Airway inflammation upper and lower airways will be assessed by collection of nasal fluid (nasal sponge will be inserted in nostril for 5 minutes), Fraction of exhaled Nitric Oxide measurement and sputum induction. * Upper and lower airway symptoms will be assessed by questionnaires (SinoNasal Outcome Measure-22, Visual Analogue Score, Asthma Symptom Score and Juniper Score) * Allergy will be assessed by skin prick test (on skin) and immunocap test (in blood, 1 tube of 10 ml). * Lung function and nasal patency will be measured by spirometry and Peak Nasal Inspiratory Flow measurement. * Exercise induced bronchoconstriction will be assessed by eucapnic voluntary hyperventilation test. Measurements immediately after training: * Collection of nasal fluid * Assessment of upper airway symptoms (Visual Analogue Score) * Spirometry and Fraction of Exhaled Nitric Oxide measurement * Peak Nasal Inspiratory Flow measurement Measurements 24 hours after training: * Collection of nasal fluid * Assessment of upper airway symptoms (Visual Analogue Score) * Spirometry and Fraction of Exhaled Nitric Oxide measurement * Peak Nasal Inspiratory Flow measurement * Sputum induction * Venous puncture (1 tube of 10 ml)