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TERMINATEDNA

Effect of Exercise on Insulin Resistance

NCT01941277•Alere San Diego

Summary

The purpose of this study is to evaluate the effect of exercise on Insulin Resistance (IR) in subjects who do not routinely exercise and who are at risk of developing diabetes (prediabetes). It is estimated that approximately 30-90 people will participate in this study at three study sites in the United States and United Kingdom.

Eligibility

Age

18 - 75 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. Aged 18 to 75 years.
•2. Meets one of the three diagnostic criteria listed below (based on screening results or recorded result within one week of enrollment);
•1. Fasting plasma or whole blood glucose (fasting defined as no caloric intake for at least 8 hours): 100 ≤ 125 mg/dL (6.0-6.9 mmol/L)
•2. HbA1c of 5.7% - 6.4% (39 - 46 mmol/mol)
•3. 2-hour plasma glucose of 140-199 mg/dL (7.8-11.0 mmol/L) during an OGTT (as described by the WHO using a glucose load of 75 g anhydrous glucose dissolved in water)
•3. No clinically significant adverse exercise response during the maximal graded exercise test

Exclusion Criteria

•1. Weight loss diet program or weight change (\>10%) within the past 6 months
•2. Daily physical activity of \>10,000 steps per day (as measured during the interval between visits 1 and 2)
•3. Participates in deliberate structured exercise
•4. Pregnant or intending to become pregnant
•5. Cognitive or intellectual disability that prevents subject from providing informed consent or following protocol instructions.
•6. Unwillingness to participate in all study procedures
•7. Inability to give blood through multiple venous phlebotomies or to have an intravenous catheter
•8. BMI greater than 40 kg/m2
•9. Concurrent participation in another lifestyle modification trial
•10. Diagnosis of diabetes based on any one of the following criteria:
+10 more criteria

Locations (2)

Manchester University

Manchester, United Kingdom

Move Lab

Newcastle upon Tyne, United Kingdom

Key Dates

Start Date

August 1, 2014

Primary Completion Date

March 1, 2015

Completion Date

March 1, 2015

Last Updated

January 3, 2024

Enrollment

ACTUAL participants

Conditions

Prediabetic State

Interventions

Current Recommendations Exercise Group

BEHAVIORAL

Intensive Exercise Group

BEHAVIORAL

Role of Aging and Individual Variation in Exercise Training Responsiveness

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Prediabetic StateCardiovascular Diseases+2 more

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RECRUITINGNA

PreventT2 Together: Examining the Efficacy of Couple-based Lifestyle Intervention to Prevent Type 2 Diabetes

NCT06690788

Prediabetic StateLife Style+4 more

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 3, 2024Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Effect of Exercise on Insulin Resistance

Inclusion Criteria

Exclusion Criteria

Role of Aging and Individual Variation in Exercise Training Responsiveness

PreventT2 Together: Examining the Efficacy of Couple-based Lifestyle Intervention to Prevent Type 2 Diabetes

Effect of Zinc on Glucose Homeostasis

Exercise Training and Fat Metabolism in Postmenopausal Women

Efficacy of High-intensity Exercise in Women With Prediabetes

Effect of Insulin Lowering on Lipogenesis