Eltrombopag for Enhancing Platelet Engraftment in Pediatric Patients Undergoing Cord Blood Transplantation

Inclusion Criteria

• •1. Patient ≥ 1 year and \< 18 years old.
• •2. Patients receiving unmanipulated single or double UCB allogeneic grafts.
• •3. Malignant and non malignant indications for transplantation.
• •4. Myeloablative and reduced intensity conditioning regimens.
• •5. Patients must meet all other pre-transplantation criteria of the transplantation center including acceptable tests of heart, liver, kidney, and lung function (standard screening for transplantation per PI, and co-investigators).
• •6. Written informed must be obtained from the patient's guardian, and accompanying informed assent from the patient for children over 6 years old.
• •7. Able to comply with study protocol.
• •3. Hypersensitivity to eltrombopag.
• •4. Liver enzymes abnormalities:
• •Alanine aminotransferase (ALT) levels \> 3 times the upper limit of normal (ULN) or serum bilirubin \> 1.5 ULN (unless due to Gilbert's syndrome or hemolytic bilirubin).
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