Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Joslin Diabetes Center
With
ImmusanT, Inc.
Participants meeting eligibility criteria will have blood collected before and after a three-day oral gluten challenge. This blood will be tested for biomarkers associated with islet autoimmunity and gluten-specific cellular immunity.
Age
18–50
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Diagnosis of Celiac Disease by histology and serology
For those with Type-1 Diabetes, at least one anti-islet antibody
HLA-DQ2.5 genotype
You may not be if
Not following a gluten free diet for at least 12 months
Known gluten exposure within the prior 2 months
Treatment with systemic immune modifying biological agents (adalimumab, etanercept, infliximab, certolizumab pegol) in prior 6 months
Treatment with systemic immunomodulatory agents in prior 30 days
Human immunodeficiency virus infection, untreated hepatitis B virus, or hepatitis C virus infection
Nut allergy
Hemoglobin level below normal range
History of angina
Pregnant or lactating
Severe symptoms to gluten challenge in the past
Elevation in transglutaminase-IgA or deamidated gliadin peptide IgA or IgG greater than or equal to 50% above upper limit of normal
Uncontrolled complications of type-1 diabetes or celiac disease which pose a risk to participation
