Lead Sponsor

Joslin Diabetes Center

Age

18 - 40 years

Sex

ALL

Healthy Volunteers

Yes

•Group 1:
•1. Age between 18-40 years;
•2. Hispanic (we will consider a subject being Hispanic if both parents are reported as Hispanics when asked the following question: "What ethnic group do you consider that you belong to?");
•3. History of type 2 diabetes in one or both parents;
•4. BMI above 27;
•5. Not have participated in any exercise program for the 6 months prior to the beginning of the study.
•Group 2:
•1. Age between 18-40 years;
•2. Hispanic (same criteria as above );
•3. No history of type 2 diabetes in any first degree relative;
•4. BMI under 25;
•5. Not have participated in any exercise program for the 6 months prior to the beginning of the study.

•diabetes, glucose intolerance, pregnancy, smoking, cardiovascular disease, uncontrolled hypertension, renal disease, proteinuria, cancer, infectious diseases, severe GI diseases, lung disease, electrolyte abnormalities, anemia, endocrine disorders, severe dyslipidemia, peripheral vascular disease, medications: beta-blockers, any diuretic, calcium channel blockers, ACE inhibitors, angiotensin receptor blockers, niacin, glucocorticoids, any antineoplastic agent, antibiotics, psychoactive agents, bronchodilators or insulin.