Evaluation of Moclobemide, a Reversible MAO-A Inhibitor, as an Adjunct to Nicotine Replacement Therapy in Female Smokers

Exclusion Criteria

• •Hypertension;
• •Hypotension with symptoms;
• •Coronary heart disease;
• •Lifetime history of heart attack;
• •Cardiac rhythm disorder;
• •Chest pains;
• •Cardiac (heart) disorder;
• •Active skin disorder;
• •Liver or kidney disorder;
• •Gastrointestinal problems or disease other than gastroesophageal reflux or heartburn;
• •Active ulcers in the past 30 days;
• •Currently Symptomatic lung disorder/disease;
• •Brain abnormality;
• •Migraine headaches that occur more frequently than once per week;
• •Recent, unexplained fainting spells;
• •Problems giving blood samples;
• •Diabetes (unless controlled by diet and exercise alone);
• •Current cancer or treatment for cancer in the past six;
• •Other major medical condition;
• •Current psychiatric disease;
• •Suicidal ideation (within the past 10 years) or lifetime occurrence of attempted suicide;
• •Current depression;
• •Bulimia or anorexia;
• •Use (within the past 45 days) of psychiatric medications including antidepressants and anti-psychotics;
• •Use (within the past 30 days) of:
• •* Illegal drugs (or if the urine drug screen is positive for tetrahydrocannabinol (THC), Cocaine, Amphetamine, Opiates, Methamphetamines, phencyclidine (PCP), Benzodiazepines, or Barbiturates),
• •* Experimental (investigational) drugs;
• •* Any medications that are known to affect smoking cessation (e.g. clonidine);
• •* Smokeless tobacco (chewing tobacco, snuff), pipes or e-cigarettes;
• •* Wellbutrin, bupropion, Zyban, Chantix, nicotine replacement therapy or any other smoking cessation aid.
• •Use of opiate medications for pain or sleep (non-opiate medication for pain or sleep will be allowed) within the past 14 days;
• •Smokes more than one cigar a month.
• •Alcohol abuse;
• •Significant adverse reaction to nicotine patches, in the past.
• •Known hypersensitivity to moclobemide or other MAO-A inhibitors.
• •Current participation or recent participation (in the past 30 days) in another smoking study at our center or another research facility.
• •Current participation or recent participation (in the past six months) in another medical research study.