Effect of Ketoconazole on the Pharmacokinetics of Refametinib

Inclusion Criteria

• •Healthy male subject
• •Age: 18 to 45 years (inclusive) at the first screening examination / visit
• •Body mass index (BMI): 18.5 to 32 kg/m² (inclusive)
• •Ability to understand and follow study-related instructions. Subject, who is a sexually active man and has not been surgically sterilized, must consent that he uses a condom during intercourse and ensures that his female partner practices adequate contraception, or he must be willing to refrain from sexual intercourse from the beginning of the trial (signing of the informed consent) until 30 days after last study drug administration