A PET Study With RO5545965 in Healthy Male Volunteers

Exclusion Criteria

• •History of any clinically significant gastrointestinal, renal, hepatic, broncho-pulmonary, neurological, psychiatric, cardio-vascular, endocrinological, haematological or allergic disease, metabolic disorder, cancer or cirrhosis
• •History of clinically significant hypersensitivity or allergic drug reactions
• •Any suspicion or history of alcohol abuse and/or consumption of other drugs of abuse
• •Regular smoker (\> 5 cigarettes, \> 1 pipeful or \> 1 cigar per day)
• •Positive for hepatitis B, hepatitis C, or HIV infection
• •Evidence of significant cardiovascular disease or disorder
• •Participation in an investigational drug or device study within 3 months prior to first administration of the study drug or within 6 times the elimination half-life, whichever is longer
• •Previous inclusion in a research and/or medical protocol or any clinical procedures involving nuclear medicine, PET, occupational exposure to ionizing radiation or radiological investigations with significant exposure to radiation, excluding dental X-ray and common X-rays of chest or extremities
• •Subject has any condition that would prevent an MRI from accurately or safely being performed \[eg, claustrophobia, cardiac pacemaker, metallic implants or clips\]
• •Subject unable to lie on his back in the PET or MRI scanner for a period of 90 minutes
• •Contraindication for arterial cannulation
• •Unsuitable veins for repeated venipuncture