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UNKNOWNPhase 1/2NCT01919866

Safety Study of CD3/CD19 Depleted Haploidentical Stem Cells

Feasibility and toxicity of haploidentical transplantation of CD3/CD19 depleted stem cells in combination with a toxicity reduced conditioning regimen or with standard conditioning regimens according ...

Lead sponsor: University Children's Hospital Tuebingen•5 locations•View source on ClinicalTrials.gov

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Contacts

Peter Lang, MD

CONTACT

+4970712981386 peter.lang@med.uni-tuebingen.de

Rupert Handgretinger, MD

CONTACT

+4970712984744 rupert.handgretinger@med.uni-tuebingen.de

Sponsors

Lead Sponsor

University Children's Hospital Tuebingen

Age

1 - 25 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•patients with primary refractory or relapsed disease (including relapse after previous SCT and active disease)
•AML in complete remission of refractory
•MDS RAEB-t/secondary AML
•ALL
•CML
•Non-Hodgkin Lymphoma / Hodgkin Lymphoma
•non malignant diseases (aplastic anemia, thalassemia, SCID)
•relapsed Neuroblastoma
•relapsed soft tissue sarcoma (Rhabdomyosarcoma, Ewing sarcoma, PNET
•soft tissue sarcoma with primary bone metastases or bone marrow
•in whom no matched donor was available,

Exclusion Criteria

•\< 6 months after previous HSCT
•active cerebral seizure conditions
•massive progression of leukemias or solid tumours before planned trp.
•left ventricular ejection fraction \<25%
•creatinine clearance \<40ml/min before conditioning
•respiratory insufficiency with oxygen demand or DLCO \<30%
•Bilirubin \>4mg/dl, GOT/GPT \>400
•severe infection (HIV, Aspergillosis)
•pregnancy

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: October 8, 2014Terms

Trial snapshot

StatusUNKNOWN

PhasePHASE1/PHASE2

Enrollment120

Start dateMar 2004

Last updatedOct 8, 2014

Condition

Acute Leukemias Aplastic Anemia Childhood Solid Tumor

Locations shown

University Children's Hospital

Graz

University Children's Hospital

Halle

Medizinische Hochschule Zentrum für Kinderheilkunde

Hanover

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: October 8, 2014Data synced to Clareo: May 3, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions