Multi-Center Study of Iron Overload: Survey Study (MCSIO)

Exclusion Criteria

• •Patients with HbSC, HbS/β thalassemia
• •Pacemaker (active or inactive) or other implanted magnetic devices, severe claustrophobia, or other contraindications to MRI; Unable to remove ferro-magnetic objects from the body in regions to be imaged (e.g., jewelry or piercing)
• •Presence of any other condition which, in the opinion of the investigator, would make the patient unsuitable for enrollment;
• •Any chronic inflammatory illness other than the SCD, THAL or DBA;
• •Any acute illness within a 14 day period prior to blood sampling;
• •Patients receiving intensive chelation in the 6 months prior to enrollment including deferoxamine 24 hours per day, 7 days per week or combination treatment with 2 chelators
• •Pregnancy