Lead Sponsor

UNC Lineberger Comprehensive Cancer Center

Collaborators

Age

18 - 75 years

Sex

FEMALE

Healthy Volunteers

No

•Be between the ages of 18-75 years old
•Have a confirmed diagnosis of type I endometrial cancer (endometrioid) based on pre-operative endometrial biopsy or dilation and curettage (D\&C)
•Be obese (BMI greater than or equal to 30) with or without diabetes
•Have no contraindications to short-term metformin therapy
•Have a serum creatinine greater 1.0 mg/dL
•Have normal serum transaminase values (AST and ALT)
•Need to be able to undergo metformin treatment for a minimum of 1 weeks but no more than a maximum of 4 weeks prior to surgical staging

•Are currently taking metformin or have taken metformin in the past 6 months or have a history of an allergic reaction or intolerance at any time to metformin
•Have a history of liver or renal dysfunction
•Have a history of alcoholism
•Have a history of vitamin B12 deficiency
•Are pregnant
•Are currently taking insulin
•Are currently taking any hormonal therapy or have been on hormonal therapy in the past 4 weeks
•Are taking a drug that may significantly interact or influence the metabolism of metformin
•In the opinion of the investigator, the patient is felt not to be appropriate for the study