Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of California, San Francisco
With
US Department of Veterans Affairs
Age
12–17
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Adolescents 12 to 17 years old under clinical care at the UCSF WATCH clinic
Body mass index\> 95th percentile for age and gender according to the Centers for Disease Control and Prevention 2000 growth charts for the United States
Insulin resistant after 6 months of healthy diet and exercise
Able to understand the assent form
You may not be if
Patients with known cardiac disease
Patients with contraindications to metformin as listed below:
* Renal disease or renal (serum creatinine levels ≥1.5 mg/dL for males, and ≥1.4 mg/dL for females;
* Known hypersensitivity to Metformin;
* Acute or chronic metabolic acidosis;
Patients with contraindications to MRI including:
* Cardiac pacemaker;
* Claustrophobia;
* Metallic foreign body in the eye,
* Aneurysm clip in the brain
Pregnancy;
Patients who could not stay still for 30 minutes within the MRI scanner due to other reasons besides claustrophobia
Clareo Health | Cardiovascular Effects of Metformin on Obesity
