BMI \> 44.0 kg/m2

Red blood cell transfusion within 11 weeks prior to the Screening visit

Androgen therapy within the previous 21 days prior to the Screening visit

Intravenous iron within the past 4 weeks prior to the Screening visit

AST or ALT \>1.8x ULN, alkaline phosphatase \>2x ULN, or total bilirubin \>1.5x ULN

Screening ECG with QTc \> 500 msec

Uncontrolled hypertension

Class III or IV congestive heart failure

Myocardial infarction, acute coronary syndrome, or stroke within 6 months prior to the Screening visit

20-Week Repeat Oral Dose Study of AKB-6548 in Participants With Chronic Kidney Disease and Anemia