A Safety and Efficacy Study of Obinutuzumab Alone or in Combination With Chemotherapy in Participants With Chronic Lymphocytic Leukemia

Exclusion Criteria

• •Participants who have received more than 3 previous CLL treatment lines
• •Documented transformation of CLL to aggressive lymphoma (Richter's transformation)
• •Participants who are refractory to immunochemotherapy
• •Participants with abnormal laboratory values
• •One or more individual organ/system impairment score of 4 as assessed by the cumulative illness rating scale (CIRS) definition, excluding the eyes, ears, nose, throat and larynx organ systems
• •Participants with a history of progressive multifocal leukoencephalopathy (PML)
• •History of severe allergic or anaphylactic reactions to monoclonal antibody therapy
• •Known hypersensitivity to the study drugs
• •History of prior malignancy unless the malignancy has been treated with a curative intent and in remission without treatment for greater than or equal to (\>/=) 5 years prior to enrollment and with the exception of curatively-treated basal cell carcinoma, squamous cell carcinoma of the skin, low grade in situ carcinoma of the cervix, or low grade, early stage localized prostate cancer treated surgically with curative intent
• •Regular treatment with corticosteroids during the 28 days prior to the start of Cycle 1, Day 1, unless administered for indications other than CLL at a dose equivalent to less than or equal to (\</=) 30 milligrams per day (mg/day) prednisone
• •Regular treatment with immunosuppressive medications following previous organ transplantation
• •Evidence of significant, uncontrolled concomitant diseases
• •Known active bacterial, viral, fungal, mycobacterial, parasitic, or other infection (excluding fungal infections of the nail beds) or a major episode of infection requiring treatment with intravenous (IV) antibiotics or hospitalization within 28 days prior to the start of Cycle 1, Day 1
• •Vaccination with live vaccines within 28 days prior to start of Cycle 1, Day 1
• •Major surgery (within 28 days prior to the start of Cycle 1, Day 1), other than for diagnosis
• •Positive for chronic hepatitis B, hepatitis C, human T-lymphotropic virus 1 (HTLV 1) or human immunodeficiency virus (HIV) infection
• •Pregnant or lactating women
• •Fertile men or women of childbearing potential
• •Participation in another clinical trial with drug intervention within 28 days prior to start of Cycle 1, Day 1 and during the study