Initiated 1st antipsychotic treatment within the past 12 months and/or has had symptoms lasting \<2 years

Current diagnosis of alcohol or drug use disorder, moderate or severe

Clinically significant or unstable medical illness, condition, or disorder

Pregnant or breastfeeding

Significant changes in diet or exercise regimen or plans to join a weight management program during the study

Opioid medications taken within 14 days and/or need to take opioid medication during the study period

History of hypersensitivity to or intolerance of olanzapine

Use of olanzapine, clozapine, mesoridazine, chlorpromazine, or thioridazine for more than 1 week during the past year

A Study of ALKS 3831 in Adults With Schizophrenia