Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Corewell Health West
With
EKOS Corporation
Age
18–80
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Patients with acute (\< or = 14 days)symptomatic pulmonary embolism by CT Angiogram of the thorax with embolus involving at least one main or lower lobe pulmonary artery and RV:LV ratio \> 0.9
You may not be if
age \> 80
Recent thrombolytic therapy (with in 4 days)
Active bleeding or know bleeding diathesis
Known coagulopathy (including treatment with vitamin K antagonists) INR \> 3 and/or PTT \> 50
Thrombocytopenia (PLT cound \< 100,000)
History of any intracranial or intraspinal surgery, trauma or bleed
Intracranial neoplasms, AVM, or aneurysm
Recent (\< 1 month) GI bleed
Recent (\< 3 months) internal eye surgery or hemorrhagic retinopathy
Recent (\< 7 days) major surgery, trauma, or obstetrical delivery
Renal insufficiency with eGFR \< 45 ml/min
Known allergy, hypersensitivity, or thrombocytopenia from heparin or tPA
Hemodynamic instability defined as need for cardiopulmonay resuscitation, Systolic BP \> 90 mm Hg for \> 15 min or need for pressor agents to maintain BP \> 90.
Severe Hypertension (sustained systolic \> 180 mm Hg or diastolic \> 90 mm Hg.
Pregnant patients
known right to left shunt
Large (\>10 mm)intracardiac thrombus
Use of thrombolytics or glycoprotein IIb/IIIa antangonists within 3 days of inclusion.
