Saves the questions and what to expect into your notes, next to the visit they belong to.
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Lead
Pontificia Universidad Catolica de Chile
The high arterial blood pressure has been correlated with an increase in pain threshold in animal and humans. One of the explanations to this phenomenon is a baroreceptor activity and vasopressin release at the level of spinal cord dorsal horn and hypothalamus.
As far as we know, there is only one study about the effect of chronic hypertension on postoperative pain and none with acute hypertension. We therefore decided to conduct a randomized controlled trial to evaluate the effect of acute hypertension on postoperative morphine's requirements.
Age
20–60
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
American Society of Anesthesiology patient classification status(ASA) I-II
Between 20 and 60 years of age
Programed for elective laparoscopic cholecystectomy
You may not be if
History of arterial hypertension
Baseline blood pressure over 139/89
Use of opioids and any analgesic drug during the last 24 hours before surgery
Chronic use of nonsteroidal antiinflammatory
BMI \> 34.9
History of drug or alcohol abuse
Use of medications that interfere in the central nervous system
Adverse reactions to the drugs used in the study
Pregnancy
Clareo Health | Effect of Acute Arterial Hypertension on Morphine's Requirements and Postsurgical Pain.
