Pregnant and lactating women

Previous treatment with immunosuppressive agents in the last 12 months prior to enrollment

Recent MS relapse in the month prior to enrollment

Treatment with oral or parenteral steroids for any cause in the month prior to enrollment

Significant systemic medical disorders including cardiac, renal, hepatic, hematologic, immunologic or endocrine disorders

Previous treatment with interferons or glatiramer acetate in the 3 months prior to enrollment

Any contra-indication for magnetic resonance imaging (MRI) or gadolinium contrast.

Positive serology for HIV, Hepatitis B or Hepatitis C

Any history of malignancy or exposure to radiation at any time prior to enrollment

Any contra-indication to lumbar puncture

Severe cognitive impairment that would interfere with the patient's ability to understand and sign the informed consent.

Safety and Efficacy Study of Autologus Bone Marrow Mesenchymal Stem Cells in Multiple Sclerosis