1. Diagnosis of polycystic ovary syndrome (by ultrasound or hyperandrogenic symptoms)

2. Fish or seafood allergy or hypersensitivity (e.g., anaphylactic reaction) to omega-3-acid ethyl esters or any component of the formulation

3. Coagulopathy or receiving therapeutic anticoagulation (due to potential for interaction with omega-3 FA)

4. History of chronic disease affecting hormone production, metabolism or clearance (including diabetes mellitus)

5. Abnormal renal or liver function at screening

6. Current use of thiazolidinediones or metformin (known to interact with reproductive hormones)

7. Use of hormones affecting hypothalamic output (HPO) axis (such as hormonal contraceptives) within three months of entry

8. Strenuous exercise (\>4 hours of intense physical activity per week)

9. Pregnancy

10. Breast-feeding

11. Current active attempts to conceive

12. History of significant recent weight loss or gain

Effects of Dietary Omega-3 Fatty Acids on Reproductive Hormones in Obese Women