Phase 1 Single Dose Study of ALXN1101 in Healthy Volunteers

Exclusion Criteria

• •1. Pregnant or nursing female subjects
• •2. QTcF \> 450 msec for males and \> 470 msec for females, or a family history of Long QT Syndrome.
• •3. CrCl \< 80 mL/min
• •4. CBC in acceptable range; SGOT or SGPT above the ULN
• •5. HIV, Hepatitis B or Hepatitis C virus infection
• •6. Other active systemic infection or malignancy
• •7. Investigational drug study within 60 days
• •8. Major surgery within the prior 90 days
• •9. History of illicit drug use or chronic alcohol dependence within 2 years prior to this study
• •10. Positive urine drug toxicology screen or serum alcohol test
• •11. Alcohol consumption within 48 hours prior to study drug administration
• •12. Recently donated or lost ≥ 499 mL of blood
• •13. Recent hormone replacement therapy or use of prescription medications