The Effect of Testosterone Topical Solution (LY900011) in Hypogonadal Men With Suboptimal Response to a Topical Testosterone Gel

Exclusion Criteria

• •Any previous treatment with testosterone topical solution (LY900011)
• •Known or suspected carcinoma (or history of carcinoma) of the prostate or suspicious nodules on digital rectal exam at Screening
• •Known or suspected breast cancer or history of breast cancer
• •Severe sleep apnea (untreated or unsuccessfully treated) in the opinion of the study investigator
• •Use of long-acting IM testosterone undecanoate in the 6-month period prior to Screening
• •History of the use of an implanted testosterone pellets (Testopel)
• •International Prostate Symptom Score (IPSS) total score \>19 at Screening
• •Hematocrit ≥50% at Screening. For sites located at elevations ≥4500 feet, participants will be excluded with hematocrit \>54% according to investigator discretion. Any participant with a hematocrit \>54% at later study visits will be withdrawn from the study
• •Significant history of allergy and/or sensitivity to the drug products or excipients, including any history of sensitivity to testosterone and/or sunscreens
• •Dermatologic condition in underarm area that might interfere with testosterone absorption (for example, eczema) or that could be exacerbated by topical testosterone replacement therapy
• •History of luteinizing hormone-releasing hormone (LHRH) antagonist or agonist treatment in the 6 months prior to Screening
• •Exhibit any evidence of congestive heart failure \[New York Heart Association (NYHA) Class 2 or above\] within 6 months prior to Screening
• •Exhibit evidence of severe renal impairment \[creatinine clearance \<30 milliliter per minute (mL/min) as determined by the Cockcroft-Gault formula\] at Screening
• •Exhibit a history of severe liver disease or clinical evidence of hepatic impairment at Screening
• •Any condition that would interfere with the participant's ability to provide informed consent, or comply with study instructions, or would place the participant at increased risk, or might confound the interpretation of the study results
• •Are investigator site personnel directly affiliated with this study and/or their immediate families. Immediate family is defined as a spouse, parent, child, or sibling, whether biological or legally adopted
• •Are currently enrolled in, or discontinued within the last 30 days from, a clinical trial involving an investigational product or non-approved use of a drug or device (other than the investigational product used in this study), or are concurrently enrolled in any other type of medical research judged not to be scientifically or medically compatible with this study