A Study of LY3015014 in Participants With High Cholesterol

Exclusion Criteria

• •Have high cholesterol due to another disease or have a rare and serious form of hereditary high cholesterol
• •Have had recent heart attack, stroke, blood clot or heart surgery, have planned heart or blood vessel surgery, or has a heart that does not pump sufficiently well
• •Have poorly controlled high blood pressure
• •Have diabetes that requires an injectable medication (including insulin), or have diabetes that is poorly controlled
• •Have thyroid blood test that is outside normal range
• •Have a history of adrenal gland disorder
• •Have a history of vitamin E deficiency or fat malabsorption syndrome
• •Have poor kidney function
• •Have active liver or gall bladder disease, history of hepatitis or liver blood tests that are high
• •Have a history of muscle disease including muscle damage from a medicine or muscle blood test that is high
• •Are anemic (low red blood cell counts)
• •Have a history of allergy or intolerance to other antibody medications
• •Have a history of human immunodeficiency virus infection (HIV) infection
• •Are likely to have a major operation or be hospitalized during the study
• •Have chronic alcohol or drug abuse or dependency
• •Have or suspected to have any cancer or malignant tumor
• •Have an active serious infection
• •Have started or stopped taking a statin or ezetimibe medication, or changed statin dose regimen recently
• •Are on a statin regimen other than daily dosing (for example, an every-other-day statin regimen)
• •Have recently used simvastatin (highest dose level), fibrates, bile acid binders, niacin, probucol, or over-the-counter/health food preparations to lower cholesterol (such as red yeast rice, fish oil, omega 3 fatty acid)
• •Have undergone LDL apheresis in the past 1 year
• •Have recently used steroids, cyclosporine or isotretinoin
• •Have recently used an immunosuppressive therapy
• •Have recently received treatment with another antibody medication
• •Are currently using medications injected into the skin , except for single injections (for example flu vaccines) or injections into muscles
• •Are currently on a prescription or over-the-counter medicine for weight loss or are on a very low carbohydrate diet