Chronic Kidney Disease in Relation to Alterations in Protein and Amino Acid Metabolism and Function

Exclusion Criteria

• •Any condition that may interfere with the definition 'healthy subject' according to the investigator's judgment (healthy subjects only)
• •Established diagnosis of malignancy
• •Established diagnosis of Insulin Dependent Diabetes Mellitus
• •History of untreated metabolic diseases including hepatic disorder
• •Presence of acute illness or metabolically unstable chronic illness
• •Presence of fever within the last 3 days
• •Body mass index \>40 kg/m2 (healthy subjects only)
• •Any other condition that would interfere with the study or safety of the patient (according to the PI or nurse)
• •Use of protein or amino acid containing nutritional supplements within 5 days of first study day
• •Use of long-term oral corticosteroids or short course of oral corticosteroids within 4 weeks preceding first study day
• •Failure to give informed consent or Investigator's uncertainty about the willingness or ability of the subject to comply with the protocol requirements
• •(Possible) pregnancy