Clinically significant abnormalities in medical history or physical exam

Show evidence of uncorrected hypothyroidism or hyperthyroidism hormone results

History of renal transplantation or renal dialysis

History of liver disease

History of greater than 3 episodes of severe hypoglycemia within 6 months of screening

Use of oral anti-diabetic medication other than metformin within 3 months of screening

History of diabetic ketoacidosis

Any other significant illness or condition that may interfere with the patient participating or completing the study

Inability or unwillingness to comply with protocol or study procedures

Safety, Tolerability and Efficacy of ISIS-GCGRRx in Type 2 Diabetes