Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University at Buffalo
Patients who take Aubagio will have an MRI, eye test, have blood taken, and complete a questionnaire on environmental risk factors to evaluate changes in the brain and on disease progression. A healthy control group will also complete the same testing regimen.
Age
18–65
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Subjects aged 18-65
Clinically definite MS according to the Polman criteria, 52
Relapsing MS or Healthy Control (no neurological disorders)
Expanded Disability Status Scale (EDSS) scores ≤5.5
Disease duration \<30 years
Normal kidney function (creatinine clearance \>59 mL/min) (patients only)
Signed informed consent
You may not be if
MS patients with hepatic impairment
Nursing mothers or pregnant women who will need to undergo 12 months follow-up
Women of childbearing potential not using reliable contraception
Patients currently treated with leflunomide
Serum alanine aminotransferase (ALT) \>1.5 times the upper limit of normal
A clinically significant infectious or neurological (for HC only) illness (e.g., cellulitis, abscess, pneumonia, septicemia) within 30 days prior to treatment assignment
Unwillingness or inability to comply with the requirements of this protocol including the presence of any condition (physical, mental, or social) that is likely to affect the subject's ability to comply with the study protocol
Any other reasons that, in the opinion of the Investigator, indicate that the subject is unsuitable for enrollment into this study
