Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of California, Los Angeles
With
National Institute on Drug Abuse (NIDA)
Age
60–80
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Subjects will be 60 heavy users or non-users between 60-80 years of age
Participants who used marijuana during adolescence. Current marijuana usage not allowed and subjects must complete urine screening at the time of inclusion.
You may not be if
Major psychiatric disorders, such bipolar disorder or schizophrenia as revealed by the Structured Clinical Interview for DSM-IV Disorders (100) and exclude for confounding psychiatric conditions
Evidence of untreated depression as determined by a HAM-D Score of \>12 (17-item version) or untreated anxiety by a score of \> 8 on the Hamilton Anxiety Scale
Evidence of neurologic or other physical illness that could produce cognitive deterioration.
Volunteers with a history of TIAs, carotid bruits, or lacunae on MRI scan will be excluded
History of myocardial infarction within the previous year or unstable cardiac disease
Uncontrolled hypertension (systolic BP \> 170 or diastolic BP \> 100)
History of significant liver disease
Clinically significant pulmonary disease, diabetes, or cancer
Because medications can affect cognitive functioning, subjects needing medicines that could influence psychometric test results will be excluded. These include: centrally active beta-blockers, narcotics, clonidine, anti-Parkinsonian medications, systemic corticosteroids, benzodiazepines, medications with significant cholinergic or anticholinergic effects, anticonvulsants, or warfarin, and any affecting the serotonin system, which may affect neuropsychological test results.
Current diagnosis or history of alcoholism or dependence on any illicit drugs other than marijuana.
Use of any investigational drugs within the previous month or longer, depending on drug half-life.
Contraindication for MRI scan (e.g. metal in body, claustrophobia).
