Mechanisms of Immune Reconstitution & Reduced Immune Activation Following Darunavir-based ART

Inclusion Criteria

• •Willing to sign consent form
• •Naïve to ART (remote ART use \>5 years will be considered on a case by case basis)
• •No known GI or cardiovascular disease
• •Between the ages of 18 and 60
• •No active opportunistic infections or therapy for acute OI within 30 days of entry. Subjects can be on secondary prophylaxis with a history of AIDS defining illness.
• •All women of childbearing potential (WCBP) must have a negative urine pregnancy test before any of the invasive or radiation exposure study procedures.
• •Normal population should be free of chronic metabolic conditions such as diabetes, hypercholesterolemia, or coronary artery disease
• •There are no CD4+ T-cell count or HIV plasma viral load restrictions.