A Multi-Center Study To Evaluate Multiple Doses of NT100 Following IVF In Women With Repeated IVF Failures (Thrive-IVF)

Inclusion Criteria

• •Pre-menopausal female 21-38 years of age at screening
• •History of repeated IVF failures despite transfer of good-quality embryos, defined as follows:
• •...1) 3 or more IVF cycles involving transfer of at least two good-quality cleavage-stage embryos or at least one good-quality blastocyst (2010 SART (Society for Assisted Reproductive Technologies) grading criteria)that resulted in one of the following outcomes:
• •\* .....a) no pregnancy
• •\* .....b) biochemical pregnancy
• •\* .....c) spontaneous abortion of an intrauterine clinical pregnancy before or equal to completed Week 8 of gestation
• •...2) At least two of the eligible IVF failures must have involved transfer of fresh embryos
• •...3) At least two of the eligible IVF failures must have involved retrieval of at least 5 oocytes
• •...4) No live birth, abortion later than Week 8 of gestation, or stillbirth may have occurred since the first of these IVF failures
• •Body mass index (BMI) of 19-38 kg per m2 at screening
• •TSH (thyroid-stimulating hormone) less than or equal to 4.0 mIU/L(milli-International units per Liter) for subjects with no history of hypothyroidism, or TSH less than or equal to 2.5 mIU/L for subjects with a history of hypothyroidism, at screening