The Effect of Calcitriol on Progress and Activity of Lupus Nephritis

Exclusion Criteria

• •Pregnancy, lactating or childbearing potential without effective method of birth control
• •Severe gastrointestinal disorders that interfere with their ability to receive or absorb oral medication
• •History of malignancy, including leukemia and lymphoma within the past 2 years; Systemic infection requiring therapy at study entry
• •Any other severe coexisting disease such as, but not limited to, chronic liver disease, myocardial infarction, cerebrovascular accident, malignant hypertension
• •History of drug or alcohol abuse within past 2 years
• •Vitamin D deficiency(25 hydroxy vitamin D less than 20ng/ml)
• •Participation in any previous trial on vitamin D analogue
• •Patients receiving treatment of vitamin D and/or its analogue for other medical reasons within the past 4 weeks
• •Patients who are taking multivitamin supplement that contains vitamin D could be enrolled after 4 weeks of wash out period by changing to a preparation that has no vitamin D
• •On other investigational drugs within last 30 days
• •History of a psychological illness or condition such as to interfere with the patient's ability to understand the requirement of the study
• •History of non-compliance; Known history of sensitivity or allergy to vitamin D analogs