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Keep this study
Lead
UNC Lineberger Comprehensive Cancer Center
The primary objective of this study is to estimate the rate of radiation-associated regional myocardial perfusion defects in patients 6 months after breast/chestwall radiation with DIBH for left-sided breast cancer. Cardiac perfusion will be assessed using SPECT cardiac perfusion scans pre- and 6 months post-radiation.
Age
18–99
Sex
FEMALE
Healthy volunteers
Not accepted
You may be eligible if
signed an Institutional Review Board (IRB)-approved informed consent document for protocol
age \>= 18 years
histologically confirmed left-sided breast cancer scheduled to undergo curative intent radiation treatment post lumpectomy or mastectomy
stage 0-III left-sided breast cancer (including DCIS)
SPECT score of 0 at baseline
radiation oncologist agrees target volume coverage will not be compromised via use of the DIBH technique along with conformal field shaping
You may not be if
active cardiac disease, defined as a history of angina, arrhythmias, myocardial infarction, congestive heart failure, or any other cardiac condition, which in the opinion of the treating physician would make this protocol unreasonably hazardous for the patient
symptomatic pulmonary disease currently requiring regular medication including but not restricted to bronchodilators
concurrent chemotherapy
prior receipt of mediastinal radiation therapy
pregnant or lactating women
inability to understand and follow breathing instructions for the DIBH procedure
