Extended Release Naltrexone for Opioid-Dependent Youth

Exclusion Criteria

• •Liver function test levels (Alanine Transaminase, Aspartate Transaminase) four times greater than normal;
• •Unstable medical or psychiatric illness (e.g., schizophrenia) that might make participation hazardous;
• •History of serious suicide attempt in the past 6 months;
• •History of allergic reaction to naloxone, and/or naltrexone;
• •Current chronic pain condition for which opioids are deemed necessary for ongoing care;
• •blood coagulation disorder (e.g., hemophilia);
• •Body Mass Index \> 40;
• •If female, pregnant, lactating, unwilling or unable (due to parental objection) to use FDA-approved contraceptive methods;
• •meeting DSM-IV criteria for benzodiazepine dependence