Clareo Health | Intra-arterial Hepatic Beads Loaded With Irinotecan With Concomitant Chemotherapy With FOLFOX in Patients With Colorectal Cancer With Unresectable Liver Metastases: a Phase II Multicenter Study
Intra-arterial Hepatic Beads Loaded With Irinotecan With Concomitant Chemotherapy With FOLFOX in Patients With Colorectal Cancer With Unresectable Liver Metastases: a Phase II Multicenter Study
Good renal function: creatinine clearance ≥ 60 mL / min
No cardiac dysfunction: no cardiovascular events in the last 6 months or no NYHA ≥ 2
You may not be if
Patient eligible for curative treatment (resection and / or radiofrequency ablation) by a multidisciplinary decision (including the opinion of a liver surgeon)
Pregnant or lactating woman or patients of both sexes and of childbearing age not using adequate contraception
History of cancer, except skin cancer (other than melanoma), carcinoma in situ of the cervix uteri treated curative. Other cancers treated with curative intent are permitted provided they did not relapse over the last 5 years
Peripheral neuropathy
Inflammatory Bowel Diseases
Intestinal obstruction
Chronic liver disease (viral, alcoholic or metabolic)
Immune Deficiency Syndromes (history of transplantation, infection with HIV)
Known to have contraindications to 5FU, oxaliplatin, folinic acid, irinotecan or to contrast products
Patients with known contraindications against hepatic embolization procedures:
Presence of biliary-digestive anastomosis or biliary stent Cruoric or tumor thrombosis of the portal vein
Patient who for psychological, social, family or geographical reasons could not be followed up regularly
Legal disability (persons deprived of liberty or under guardianship)
Patient is not affiliated to a social security scheme
Participation in another concurrent study investigating the effect of treatment and this until 4 weeks after the end of the concurrent study.
