Institut National de la Santé Et de la Recherche Médicale, France
National Research Agency, France
Age
60–any
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Native language: French
Medical, neurological, neuropsychological and neuroradiological depth in accordance with the criteria for inclusion and exclusion-specific population, that is to say:
* Healthy Elderly volunteers: over 60 years old, living at home, without memory complaints, normal performances compared to the age and the educational level for all tests of the diagnostic battery.
* Alzheimer's patients: presenting the standard criteria of NINCDS-ADRDA probable Alzheimer's disease, including abnormal global cognitive function and deficits in at least two cognitive domains identified by the diagnostic battery.
You may not be if
The sudden onset of cognitive impairments (as opposed to their slow and gradual installation in Alzheimer's disease)
A chronic neurological, psychiatric, endocrine, hepatic or infectious complaint
A history of major disease (an uncontrolled diabetes, a lung, heart, metabolic, hematologic, endocrine disease or a severe cancer);
A medication that may interfere with memory or metabolic measures
A alcohol or drugs abuse
The cons-indications to MRI (claustrophobia, metallic object in the body).
A predominantly left-hand (score below 50% in Edinburgh Inventory)
