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Non-invasive Measuring of Cerebral Perfusion After Severe Brain Injury With Near-infrared-spectroscopy and ICG | Clinical Trials | Clareo Health

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Non-invasive Measuring of Cerebral Perfusion After Severe Brain Injury With Near-infrared-spectroscopy and ICG

Continuous, Non-invasive Monitoring of Cerebral Oxygenation and Perfusion Using Near-infrared Spectroscopy With Indocyanine Green Perfusion Measurement in Patients With Traumatic Brain Injury, Intracerebral or Subarachnoid Hemorrhage

NCT01836848•University of Cologne

View on ClinicalTrials.gov

Summary

The purpose of this study is to show if it is possible to detect secondary ischemic events in patients with severe brain injury or cerebral haemorrhage with the help of non-invasive near-infrared spectroscopy (NIRS) by using the indocyanine green measuring of cerebral perfusion.

Eligibility

Age

18 - 80 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Patients over 18 years
•onset of clinical symptoms of subarachnoid or intracranial haemorrhage or trauma suffered less than 72h
•indication for implanting a tissue oxygen and intracranial pressure probe
•A signed informed consent by the patient or legal guardian

Exclusion Criteria

•Persistent epidural, subdural or subcutaneous hematoma in planned area of the NIRS optode
•Open injuries in the area of the planned optodes
•Malignant primary disease under chemotherapy
•pregnancy
•bleeding disorder
•In the short term unfavorable prognosis (eg, bilateral wide and light-fixed pupils)
•Patients with pacemakers or where no MRI compatibility is due to non- removable metal parts
•contraindications for contrast media in CT (eg, iodine allergy)
•Untreated hyperthyroidism
•End Stage Renal Disease
+1 more criteria

Locations (1)

Departement of General Neurosurgery of th University of Cologne

Cologne, Germany

Key Dates

Start Date

June 1, 2013

Primary Completion Date

December 1, 2015

Completion Date

June 1, 2016

Last Updated

April 22, 2013

Enrollment

ESTIMATED participants

Conditions

Subarachnoid Hemorrhage, AneurysmalIntracerebral Hemorrhage (ICH)Traumatic Brain Injury

Interventions

measuring cerebral perfusion by NIRS with ICG

PROCEDURE

Clinical Randomisation of an Anti-fibrinolytic in Symptomatic Mild Head Injury in Older Adults

NCT04521881

Traumatic Brain Injury

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RECRUITING

A Study to Develop a Blood-based Test for Aiding the Diagnosis/Prognosis of Traumatic Brain Injury in Adults and for Monitoring the Development of Secondary Events in Patients Diagnosed With Traumatic Brain Injury

NCT07455136

Traumatic Brain Injury

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RECRUITING

Hemodynamic ABI Monitor

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: April 22, 2013Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Non-invasive Measuring of Cerebral Perfusion After Severe Brain Injury With Near-infrared-spectroscopy and ICG

Inclusion Criteria

Exclusion Criteria

Clinical Randomisation of an Anti-fibrinolytic in Symptomatic Mild Head Injury in Older Adults

A Study to Develop a Blood-based Test for Aiding the Diagnosis/Prognosis of Traumatic Brain Injury in Adults and for Monitoring the Development of Secondary Events in Patients Diagnosed With Traumatic Brain Injury

Hemodynamic ABI Monitor

Multimodal, Enriched Environment for Rehabilitation in Chronic Traumatic Brain Injury

Carbon Dioxide Administration and Brain Waste Clearance

Transcutaneous Auricular Neurostimulation for ICU Patients With Traumatic Brain Injury