Metabolomic Analysis of Hepatic Insulin Resistance

Exclusion Criteria

• •The following will exclude subjects from study participation:
• •1. Clinically significant medical issues outside of diabetes (eg, pregnancy, cardiovascular disease, uncontrolled pulmonary disease). If female and of child bearing potential, a pregnancy test will be performed and confirmed negative prior to participation in the study and prior to the scheduled glucose clamp procedure.
• •2. A history of hematologic (platelets \<100 x107/L), hepatic (liver function tests \[LFTs\] \>2X upper limit of normal), renal (Creatinine \>1.5 mg/dL), pulmonary/ cardiac abnormalities (ie, abnormal electrocardiogram \[EKG\]).
• •3. Use of anti-diabetes medication, anticoagulants, or medication that might alter lipids. If the subject has a history of diabetes, it should be controlled by diet alone.
• •4. Inflammatory or celiac intestinal disease;
• •5. Untreated thyroid disease;
• •6. Excessive alcohol use, illicit drug use, or active untreated psychiatric disease.